Oxford Textbook of Medicine (Oxford Textbook) (6TH ed.)

Oxford Textbook of Medicine (Oxford Textbook) (6TH ed.)

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Biographical Note: John Firth, Consultant Physician and Nephrologist, Addenbrooke's Hospital, Hills Road, Cambridge, Christopher Conlon, Consultant Physician in Infectious Diseases and Tropical Medicine, Professor of Infectious Diseases, University of Oxford, Oxford, Timothy Cox, Professor of...

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Biographical Note:

John Firth, Consultant Physician and Nephrologist, Addenbrooke's Hospital, Hills Road, Cambridge, Christopher Conlon, Consultant Physician in Infectious Diseases and Tropical Medicine, Professor of Infectious Diseases, University of Oxford, Oxford, Timothy Cox, Professor of Medicine, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge



Review Quotes:

"Due to the easy to read nature of the handbook and the concise way in which is written I would recommend the book to any medical student who is studying their specialities. It has all the information in one place- perfect for note-taking and revision." -- North Wing Magazine




Table of Contents:
Section 1 - Patients and their treatment1.1. An older patient's story, Timothy M. Cox1.2. A younger patient's experience of healthcare1.3. The patient in control, Rosamund Snow1.4. What do patients need?, Des Spence1.5. Medical ethics, Mike Parker, Suleman Mehrunisha1.6. Principles of clinical decision making, Tim Peto, Philippa Peto Section 2 - Background to medicine2.1. Science in medicine: when, how, and what, William F. Bynum2.2. Evolutionary medicine, Nesse Randolph2.3. The global burden of disease, Vos Theo, Alan Lopez, and Christopher Murray2.4. Large-scale randomized evidence: trials and meta-analyses of trials, Colin Baigent, R. Collins, R. Peto, R. Gray, and S. Parish2.5. Bioinformatics, Afzal Chaudhry2.6. Clinical Pharmacology, Kevin O'Shaughnessy2.7. Biological Therapies in rheumatic diseases, John Isaacs, Nishanthi Thalayasingam2.8. Traditional Medicine exemplified by Traditional Chinese Medicine, Youyou Tu, Fulong Liao, and Jiang Tingliang2.9. Engaging patients in therapeutic development, Emil Kakkis, Max Bronstein2.10. Medicine quality, physicians and patients, Paul Newton2.11. Preventive medicine, David Mant2.12. Medical screening, Nick Wald2.13. Health promotion, Evelyne de Leeuw2.14. Deprivation and health, Harry Burns2.15. How much should rich country governments spend on healthcare?, Allyson M. Pollock and David Price2.16. Financing healthcare in low- income developing co untries: A challenge for equity in health, Luis G. Sambo, Jorge Simões, and Maria do Rosario O. Martins2.17. Research in the developed world, Jeremy Farrar2.18. Fostering medical and health research in resource-constrained countries, Malegapuru (William) Makgoba, Steve Tollman2.19. Regulation versus innovation in medicine, Michael Rawlins2.20. Human disasters, Amartya Sen2.21. Humanitarian medicine, Amy Kravitz2.22. Complementary and Alternative medicine, Edzard Ernst Section 3 - Cell biology3.1. The cell, George Banting, Paul Luzio3.2. The genomic basis of medicine, James Lupski, Pawel Stankiewicz3.3. Cytokines, Iain B. McInnes3.4. Ion channels and disease, Francis M. Ashcroft, PauloTammaro3.5. Intracellular signalling, Rodrigo Andres Floto3.6. Apoptosis in health and disease, Mark Arends, Chris Gregory3.7. Stem cells and regenerative medicine, Siddharthan Chandran, Alexis Joannides, and Ludovic Vallier3.8. The evolution of therapeutic antibodies, Herman Waldmann, Gregory Winter3.9. Circulating DNA for molecular diagnostics, Dennis Lo, Rossa Chiu Section 4 - Immunological mechanisms4.1. The innate immune system, Paul Bowness4.2. The complement system, Marina Botto, Matthew Pickering4.3. Adapative immunity, Paul Klenerman, Constantino Lopez4.4. Immunodeficiency, Dinakantha Kumararatne, Sophie Hambleton, Sara Marshall4.5. Allergy, Pamela Ewan4.6. Autoimmunity, Antony Rosen4.7. Principles of transplantation immunology, Kathryn J. Wood, Elizabeth Wallin Section 5 - Principles of clinical oncology5.1. Epidemiology of cancer, Anthony Swerdlow, Richard Peto5.2. The nature and development of cancer: cancer mutations and their implications, James Brenton5.3. The genetics of inherited cancers, Rosalind Eeles5.4. Cancer immunity and immunotherapy, Charles Drake5.5. Clinical features and management, Martin Gore, Tim Eisen5.6. Systemic treatment and radiotherapy, Rajesh Jena, Peter Harper5.7. Medical management of breast cancer, Tim Crook Section 6 - Old age medicine6.1. Ageing and clinical medicine, Neil Pendleton, Claire Steves6.2. Frailty and sarcopenia, Andrew Clegg, Harnish Patel6.3. Optimising well being into old age, Steve Iliffe6.4. Older people and acute medical illness, Simon Controy, Jay Banerjee6.5. Age atuning general hospital services, Graham Ellis, Alasdair MacLullich, and Rowan Harwood6.6. Supporting older peoples' care in other specialist services, Jugdeep Dhesi, Judith Partridge, and Jacqueline Close6.7. Drugs and prescribing, Miles Witham, Denis O'Mahony, and Jacob George6.8. Falls, Faints and Fragility Fractures, Tash Masud, Fiona Kearney6.9. Bladder and bowels, Susie Orme, Danielle Harari6.10. Neurodegenerative disorders in older people, John Hindle6.11. Promotion of healthy living, dignity and quality of life, Eileen Burns, Claire Scampion Section 7 - Pain & Pallative7.1. Introduction to palliative care, Susan Salt7.2. Pain management, Marie Fallon7.3. Management of other symptoms, Regina McQuillan7.4. Care of the dying person, Suzanne Kite, Adam Hurlow Section 8 - Infectious diseases8.1.1. Biology of pathogenic microorganisms, Duncan Maskell, James Wood8.1.2. Clinical features and general management of patients with severe infections, Duncan Young, Peter Watkinson8.2.1. Clinical approach to patient with suspected infection, Christopher Ellis8.2.2. Fever of unknown origin, Steven Vanderschueren8.2.3. Nosocomial infection, Ian C.J.W. Bowler, Matthew Scarborough8.2.4. Infection in the immunocompromised host, Jonathan Cohen, Elham Khatamzas8.2.5. Antimicrobial chemotherapy, Alisdair P. MacGowan8.3.1. Immunization, David Goldblatt, Mary Ramsay8.4.1. Travel & expedition medicine, Chris P. Conlon, Susanna Dunachie8.5.1. Respiratory tract viruses, Malik Peiris8.5.2. Herpesviruses (excluding Epstein Barr virus), Patrick Sissons8.5.3. Epstein-Barr virus, Alan B. Rickinson8.5.4. Poxviruses, Geoffrey L. Smith8.5.5. Mumps: epidemic parotitis, B.K. Rima8.5.6. Measles, H.C. Whittle, Peter Aaby8.5.7. Nipah and Hendra virus encephalitides, C.T. Tan8.5.8. Enterovirus infections, Phillip Minor, Ulrich Desselberger8.5.9. Virus infections causing diarrhoea and vomiting, Philip Dormitzer, Ulrich Desselberger8.5.10. Rhabdoviruses: rabies and rabies-related lyssaviruses, M.J. Warrell, David A. Warrell8.5.11. Colorado tick fever & other arthropod-borne reoviruses, M.J. Warrell, David A. Warrell8.5.12. Alphaviruses, Ann Powers8.5.13. Rubella, Pat Tookey, Jennifer M. Best8.5.14. Flaviviruses (excepting Dengue), Nikos Vasilakis, Shannan Rossi8.5.15. Dengue, Bridget A. Wills, Leo Yee-Sin8.5.16. Bunyaviridae, James W. LeDuc, Dennis Bente8.5.17. Arenaviruses, Jan ter Meulen8.5.18. Filoviruses, Jan ter Meulen8.5.19. Papovaviruses and polyomaviruses, Raphael P. Viscidi, Chen Sabrina Tan8.5.20. Parvovirus B19, Kevin E. Brown8.5.21. Hepatitis viruses (excluding hepatitis C virus), Matthew Cramp, Ashwin Dhanda8.5.22. Hepatitis C virus, Paul Klenerman, Jane Collier8.5.23. HIV and AIDS, Sarah Fidler, Tim Peto, Philip Goulder, and Christopher Conlon8.5.24. HIV in low- and middle-income countries, Kevin M. De Cock, Alison D. Grant8.5.25. HTLV-1, HTLV-2 and associated diseases, K (Tine) Verdonck, Eduardo Gotuzzo8.5.26. Viruses and cancer, Robin A. Weiss8.5.27. Orf and Milker s Nodule, Emma Aarons, David Warrell8.5.28. Molluscum contagiosum, David Warrell and Christopher Conlon8.5.29. Newly discovered viruses, Harriet Hughes, Susanna Froude8.6.1. Diphtheria, Delia B. Bethell, Tran Tinh Hien8.6.2. Streptococci and enterococci, Dennis L. Stevens, Sarah E. Hobdey8.6.3. Pneumococcal infections, Anthony J. Scott8.6.4. Staphylococci, Kyle Popovich, Robert Weinstein, and Bala Hota8.6.5. Meningococcal infections, Petter Brandtzaeg8.6.6. Neisseria gonorrhoeae, Magnus Unemo, Jackie Sherrard8.6.7. Enterobacteria and bacterial food-poisoning, Pennington Hugh8.6.8. Pseudomonas aeruginosa, Sharon Peacock, Gavin Koh8.6.9. Typhoid and paratyphoid fevers, Chris Parry, Buddha Basnyat8.6.10. Intracellular klebsiella infections (donovanosis and rhinoscleroma), Nicole Stoesser8.6.11. Anaerobic bacteria, Anilrudh A. Venugopal, David W. Hecht8.6.12. Cholera, A.A.M. Lima, Dick Guerrant8.6.13. Haemophilus influenzae, Esther Robinson8.6.14. Haemophilus ducreyi & chancroid, Nigel O'Farrell8.6.15. Bordetella infection, Cameron Grant8.6.16. Melioidosis & glanders, Sharon Peacock, 8.6.17. Plague: Yersinia pestis, Michael B. Prentice8.6.18. Other Yersinia infections - yersiniosis, Michael B. Prentice8.6.19. Pasteurella, Marina S. Morgan8.6.20. Francisella tularensis infection, Petra C.F. Oyston8.6.21. Anthrax, A. Brown8.6.22. Brucellosis, Juan D. Colmenero, Pilar Morata8.6.23. Tetanus, Louisa Thwaites, Lam Minh Yen8.6.24. Clostridium difficile, Mark Wilcox, David Eyre8.6.25. Botulism, gas gangrene, and clostridial gastrointestinal infections, D.L. Stevens, Michael J. Aldape, and Amy E. Bryant8.6.26. Tuberculosis, Richard E. Chaisson, Jean B. Nachega8.6.27. Disease caused by environmental mycobacteria, Jakko van Ingen, P.D.O. Davies8.6.28. Leprosy (Hansen's disease), Diana N.J. Lockwood8.6.29. Buruli ulcer: Mycobacterium ulcerans infection, W.M. Meyers, Francoise Portaels8.6.30. Actinomycosis, Klaus P. Schaal8.6.31. Nocardiosis, Roderick J. Hay8.6.32. Rat bite fevers (Streptobacillus moniliformis and Spirillum minus infection), Andrew Woodhouse8.6.33. Lyme borreliosis, John Nowakowski8.6.34. Relapsing fevers, David A. Warrell8.6.35. Leptospirosis, Nick Day8.6.36. Nonvenereal endemic treponematoses: yaws, endemic syphilis (bejel), and pinta, Michael Marks, David Mabey, and Oriol Mitja8.6.37. Syphilis, Basil Donovan, Phillip Read8.6.38. Listeriosis, Herbert Hof8.6.39. Legionelleosis and legionnaires' disease, Jordi Carratala Fernandez, Diego Viasus8.6.40. Rickettsiosis, Philippe Parola, Didier Raoult, and Karolina Griffiths8.6.41. Scrub typhus, Daniel Paris, Nicholas P. J. Day8.6.42. Coxiella burnetti infections (Q fever), Thomas J. Marrie8.6.43. Bartonelloses, excluding B bacilliformis, Bruno B. Chomel, Henri-Jean Boulouis, Matthew J. Stuckey, Jean-Marc Rolain8.6.44. Bartonella bacilliformis infection, A. Llanos-Cuentas, Ciro Maguina-Vargas8.6.45. Chlamydial infections, Patrick Horner, David Mabey, David Taylor-Robinson, Magnus Unemo8.6.46. Mycoplasmas, Jorgen Jensen, David Taylor-Robinson8.6.47. A checklist of bacteria associated with infection in humans, John Paul8.7.1. Fungal infections, Roderick J. Hay8.7.2. Cryptococcosis, William G. Powderly, 8.7.3. Coccidioidomycosis, Gregory M. Anstead, John R. Graybill8.7.4. Paracoccidioidomycosis, M. A. Shikanai-Yasuda8.7.5. Pneumocystis jiroveci, Robert F. Miller, Christopher Eades8.7.6. Taralomyces (Penicillium) marneffei infection, Khuanchai Supparatpinyo, Romanee Chaiwarith8.7.7. Microsporidiosis, Louis Weiss8.8.1. Amoebic infections, Richard Knight8.8.2. Malaria, Arjen Dondorp8.8.3. Babesiosis, Philippe Brasseur8.8.4. Toxoplasmosis, Eskild Petersen, Oliver Liesenfeld8.8.5. Cryptosporidium and cryptosporidiosis, Simone M. Caccio8.8.6. Cyclospora and cyclosporiasis, Paul Kelly8.8.7. Cystoisospora, Louis Weiss8.8.8. Sarcocystosis (sarcosporidiosis), John Cooper8.8.9. Giardiasis and balantidiasis, Lars Eckmann8.8.10. Blastocystis infection, Richard Knight8.8.11. Human African trypanosomiasis, Reto Brun, Johannes Blum8.8.12. Chagas disease, Michael Miles8.8.13. Leishmaniasis, Diana Lockwood8.8.14. Trichomoniasis, Jane R. Schwebke8.9.1. Cutaneous filariasis, G. M. Burnham8.9.2. Lymphatic filariasis, Richard Knight8.9.3. Guinea worm disease (dracunculiasis), Richard Knight8.9.4. Strongyloidiasis, hookworm & other gut strongyloid nematodes, Michael Brown8.9.5. Gut and tissue nematode infections acquired by ingestion, Peter Chiodini, David Grove8.9.6. Angiostrongylus, Richard Knight8.10.1. Cestodes (tapeworms), Richard Knight8.10.2. Cystic hydatid disease (Echinococcus granulosus), Pedro Moro, Hector H. Garcia, and Armando E. Gonzalez8.10.3. Cysticercosis, Hector H. Garcia, R. H. Gilman8.11.1. Schistosomiasis, David Dunne, Birgitte Vennervald8.11.2. Liver fluke infections, Ross Andrews, Paiboon Sithithaworn, Trevor Petney, and Khuntikeo Narong8.11.3. Lung flukes (paragonimiasis), Udomsak Silachamroon, Sirivan Vanijanonta8.11.4. Intestinal trematode infections, Alastair McGregor8.12. Non-venomous arthropods, John Paul8.13. Pentostomiasis (porocephalosis, linguatulosis/ linguatuliasis or tongue worm infection), D. A. Warrell Section 9 - Sexually transmitted diseases9.1. Epidemiology of sexually transmitted diseases, David Mabey, Anita Vas-Falcao9.2. Sexual behaviour, Catherine H. Mercer, Annie M. Johnson9.3. Sexual history and examination, Gary Brook, Jackie Sherrard, and Graziano Luzzi9.4. Vaginal discharge, Paul Nyirjesy9.5. Urethritis, Paddy Horner9.6. Ano-genital ulcers, Raj Patel, Patrick French9.7. Ano-genital lumps, Charles Lacey, Henry de Vries9.8. Pelvic inflammatory disease, Jonathan Ross9.9. Principles of contraception, Zara Haider Section 10 - Chemical and physical injuries10.1. Environmental medicine, occupational medicine and poisoning - Introduction, Jonathan Ayres10.2.1. Occupational and environmental health, Raymond Agius, Sen Debasish10.2.2. Occupational safety, Lawrence Waterman, Michelle Twigg10.2.3. Aviation medicine, Michael Bagshaw10.2.4. Diving medicine, Mark Glover10.2.5. Noise, David Koh, Tar-Ching Aw10.2.6. Vibration, Tar-Ching Aw10.3.1. Air pollution, Om Kurmi, Kin Bong Hubert Lam10.3.2. Heat, M.A. Stroud10.3.3. Cold, M.A. Stroud10.3.4. Drowning, Peter Fenner10.3.5. Lightning and electrical injuries, Chris Andrews10.3.6. Diseases of high terrestrial altitudes, Eric Swenson, Tyler J. Albert10.3.7. Radiation, Jill Meara10.3.8. Disasters: earthquakes, volcanic eruptions, hurricanes & floods, Peter J. Baxter10.3.9. Bioterrorism, Manfred Green10.4.1. Poisoning by drugs and chemicals, J.A. Vale, Nick Bateman, and Sally Bradberry10.4.2. Injuries, envenoming, poisoning, allergic reactions caused by animals, D. A. Warrell10.4.3. Poisonous fungi, D. A. Warrell, Hans Persson10.4.4. Poisonous plants, Michael Eddleston, Hans Persson Section 11 - Nutrition11.1. Macronutrient metabolism, Keith N. Frayn, Rhys Evans11.2. Vitamins, Tom Hill, David Bender11.3. Minerals and trace elements, Katherine Younger11.4. Severe malnutrition, Alan Jackson11.5. Diseases of affluent societies and the need for dietary change, Jim Mann, Stewart Truswell11.6. Obesity, Sadaf Farooqi11.7. Artificial nutrition support, Jeremy Woodward Section 12 - Metabolic disorders12.1. The inborn errors of metabolism - general aspects, Timothy M. Cox12.2. Protein-dependent Inborn errors of metabolism, George Hoffman, Stefan Koelker12.3.1. Glycogen storage diseases, Robin Lachmann, Timothy M. Cox12.3.2. Inborn errors of fructose metabolism, Timothy M. Cox12.3.3. Disorders of galactose, pentose, and pyruvate metabolism, Timothy M. Cox12.4. Disorders of purine and pyrimidine metabolism, Lynette Fairbanks, Tony Marinaki, and Richard W. E. Watts12.5. The porphyrias, Timothy M. Cox12.6. Lipid and lipoprotein disorders, James Scott, Jaimini Cegla12.7.1. Hereditary haemochromatosis, William J. H. Griffiths, Timothy M. Cox12.7.2. Inherited diseases of copper metabolism: Wilson's Disease and Menke's Disease, Pramod Mistry, Michael Schilsky12.8. Lysosomal disease, Patrick B. Deegan, Timothy M. Cox12.9. Disorders of peroxisomal metabolism in adults, Anthony Wierzbicki12.10. Hereditary disorders of oxalate metabolism the primary hyperoxalurias, Christopher Danpure, Sonia Fargue, and Dawn Milliner12.11. Disturbances of acid base homeostasis, Julian Seifter12.12.1. The acute phase response and C-reactive protein, Mark Pepys12.12.2. Hereditary periodic fever syndrome, Helen Lachmann, Philip Hawkins, and Stefan Berg12.12.3. Amyloidosis, Mark Pepys, Philip Hawkins12.13. Alpha-1 antitrypsin deficiency and the serpinopathies, David A. Lomas Section 13 - Endocrine disorders13.1. Principles of hormone action, V. Krishna Chatterjee, Mark Gurnell, and Rob Fowkes13.2.1. Disorders of the anterior pituitary gland, John Wass, Niki Karavitaki13.2.2. Disorders of the posterior pituitary gland, John Wass, Niki Karavitaki, and Shahzada K. Ahmed13.3.1. The thyroid gland and disorders of thyroid function, Anthony P. Weetman, Kristien Boelaert13.3.2. Thyroid cancer, Kristien Boelaert, Anthony P. Weetman13.4. Parathyroid disorders & diseases altering calcium metabolism, Rajesh V. Thakker13.5.1. Disorders of the adrenal cortex, Mark Sherlock, Will Drake, and Mark Gurnell13.5.2. Congenital adrenal hyperplasia, Nils Krone13.6.1. Ovarian disorders, Stephen Franks13.6.2. Disorders of male reproduction, Pierre Bouloux13.6.3. Benign breast disease, Gael M. MacLean13.6.4. Sexual dysfunction, Ian Eardley13.7.1. Normal growth and its disorders, Gary Butler13.7.2. Normal puberty and its disorders, Fiona Ryan, Sejal Patel13.7.3. Normal and abnormal sexual differentiation, Ahmed Faisal, Angela Lucas-Herald13.8. Pancreatic endocrine disorders & MEN, Stephen Bloom, Tricia Tan, and Bernard Khoo13.9.1. Diabetes mellitus, Colin Dayan, Julia Platts13.9.2. Hypoglycaemia, Mark Evans, Ben Challis13.10. Hormonal manifestations of non-endocrine disorders, John Wass, Tom Barber13.11. The pineal gland and melatonin, Jo Arendt, Tim Cox Section 14 - Pregnancy14.1. Physiological changes of normal pregnancy, David J. Williams14.2. Nutrition in pregnancy, David J. Williams14.3. Medical management of normal pregnancy, David J. Williams14.4. Hypertension in pregnancy, Fergus McCarthy14.5. Renal disease in pregnancy, Kate Wiles14.6. Heart disease in pregnancy, Catherine E. Head14.7. Thrombosis in pregnancy, Peter McCallum, Louise Bowles14.8. Chest disease in pregnancy, Tina Hartert, Meredith Pugh14.9. Liver and gastrointestinal disease during pregnancy, Cath Williamson, Michael Heneghan14.10. Diabetes in pregnancy, Bryony Jones, Anne Dornhurst14.11. Endocrine disease in pregnancy, David Carty14.12. Neurological conditions in pregnancy, Pooja Dassan14.13. The skin in pregnancy, Gudula Kirtschig, Fenella Wojnarowska14.14. Autoimmune rheumatic disorders & vasculitis in pregnancy, Cathy Nelson-Piercy, May Ching Soh14.15. Maternal infection in pregnancy, Rosie Burton14.16. Fetal effects of maternal infection, Lawrence Impey14.17. Blood disorders in pregnancy, David Perry, Katharine Lowndes14.18. Malignant disease in pregnancy, Robin A. F. Crawford14.19. Maternal critical care, Rupert Gauntlett14.20. Prescribing in pregnancy, Lucy MacKillop, Charlotte Frise14.21. Contraception for women with medical diseases, Aarthi Mohan Section 15 - Gastroenterological disorders15.1. Structure and function of the gastrointestinal tract, Satish Keshav, Michael FitzPatrick15.2. Symptoms of gastrointestinal disease, Jeremy Woodward15.3.1. Colonoscopy and flexible sigmoidoscopy, James East, Brian P. Saunders15.3.2. Upper gastrointestinal endoscopy, James East, George Webster15.3.3. Radiology of the gastrointestinal tract, Michael Maher, Fiona Moloney15.3.4. Investigation of gastrointestinal function, Jervoise Andreyev15.4.1. The acute abdomen, Justin Davies, Simon Buczacki15.4.2. Gastrointestinal Bleeding, Vanessa Brown, TA Rockall15.5. Immune disorders of the gastrointestinal tract, Arthur Kaser, Joya Bhattacharyya15.6. The mouth and salivary glands, John Gibson, Douglas Robertson15.7. Diseases of the oesophagus, Rebecca C. Fitzgerald, Massimiliano di Pietro15.8. Peptic ulcer disease, Joseph Sung, Mok Hing Yiu15.9.1. Hormones and the gastrointestinal tract, Rebecca Scott, T.M. Tan, S.R. Bloom15.9.2. Carcinoid syndrome, B. Khoo, T.M. Tan, S.R. Bloom15.10.1. Differential diagnosis and investigation of malabsorption, Alastair Forbes, Victoria Mulcahy15.10.2. Bacterial overgrowth of the small intestine, Ray Playford, Stephen Middleton15.10.3. Coeliac disease, David Sanders, Peter Mooney15.10.4. Gastrointestinal lymphomas, Kikkeri N. Naresh15.10.5. Disaccharidase Deficiency, Timothy M. Cox15.10.6. Whipple's Disease, Didier Raoult, Florence Fenollar15.10.7. Effects of massive bowel resection, Stephen Middleton, Simon Gabe, Raymond Playford15.10.8. Malabsorption syndromes in the Tropics, Vineet Ahuja, Govind Makharia15.11. Crohn's disease, Miles Parkes, Tim Raine15.12. Ulcerative colitis, Peter Irving, Jeremy Sanderson15.13. Irritable bowel syndrome, Qasim Aziz, Adam Farmer15.14. Colonic diverticular disease, Niel Mortensen, Nicholas Buchs, Roel Hompes, Shazad Ashraf15.15. Congenital abnormalities of the gastrointestinal tract, Uhlig Holm15.16. Cancers of the gastrointestinal tract, J. Bridgewater, Stephen Pereira, Peter Labib, 15.17. Vascular disorders of the GI tract, Ray Boyapati15.18. Gastrointestinal infections, Sarah O'Brien15.19. Miscellaneous disorders of the bowel, Alexander E. S. Gimson15.20. Structure and function of the liver, biliary tree and pancreas, Alexander E. S. Gimson, William Gelson15.21. Pathobiology of chronic liver disease, Wajahat Mehal15.22.1. Investigation and management of jaundice, Jane Collier15.22.2. Cirrhosis and ascites, Arroyo Vicente, Javier Fernandez15.22.3. Portal hypertension and variceal bleeding, Peter Hayes, Marcus Robertson15.22.4. Hepatic encephalopathy, Debbie Shawcross, Paul Middleton15.22.5. Liver failure, Rajiv Jalan, Jane Macnaughtan15.22.6. Liver transplantation, John O'Grady15.23.1. Hepatitis A to E, Alexander Graeme, Kate Nash15.23.2. Autoimmune hepatitis, Gideon Hirschfield, G. J. Webb15.23.3. Primary biliary cholangitis, David Jones, Jessica Dyson15.23.4. Primary sclerosing cholangitis, Roger W. Chapman, Kate Williamson15.24.1. Alcoholic liver disease, Ewan Forrest15.24.2. Non-alcoholic fatty liver disease, Quentin Anstee, Chris Day15.24.3. Drug-induced liver disease, Guruprasad Aithal15.24.4. Vascular disorders of the liver, Alexander Gimson15.24.5. The liver in systemic disease, James Neuberger15.24.6. Primary and secondary liver tumours, Michael Allison, Graeme Alexander, David Lomas15.24.7. Liver and biliary diseases in infancy and childhood, Richard Thompson15.25. Diseases of the gallbladder and biliary tree, Colin Johnson, Mark Wright15.26.1. Acute pancreatitis, Ross Carter, Colin McKay, Euan Dickson15.26.2. Chronic pancreatitis, Marco Bruno, Djuna Cahen15.26.3. Tumours of the pancreas, Steve Pereira, James Skipworth Section 16 - Cardiovascular16.1.1. Blood vessels and the endothelium, Keith Channon, Patrick Vallance16.1.2. Cardiac physiology, Rhys Evans, Kenneth MacLeod, Steven B. Marston, and Nicholas J. Severs16.2.1. Chest pain, breathlessness and fatigue, Jeremy Dwight16.2.2. Syncope and palpitation, Kim Rajappan, A. C. Rankin, A. D. McGavigan, and S. M. Cobbe16.3.1. Electrocardiography, Andrew R. Houghton, David Gray16.3.2. Echocardiography, Adrian P. Banning, Andrew R. J. Mitchell, and James D. Newton16.3.3. Cardiac investigations: nuclear, MRI and CT, Nikant Sabharwal, Andrew Kelion, Theo Karamitos, and Stefan Neubauer16.3.4. Cardiac catheterisation and angiography, Edward D. Folland16.4. Cardiac arrhythmias, Matthew Ginks, Gregory Y. H. Lip, D. Lane, S. M. Cobbe, A. D. McGavigan, and A. C. Rankin16.5.1. Epidemiology and general pathophysiological classification of heart failure, Theresa McDonagh, Kaushik Guha16.5.2. Acute heart failure: definitions, investigation and management, Andrew L. Clark, John G. F. Cleland16.5.3. Chronic heart failure: definitions, investigation and management, John G. F. Cleland, Andrew L. Clark16.5.4. Cardiorenal syndrome, Darren Green, Philip Kalra16.5.5. Cardiac transplantation and mechanical circulatory support, Jayan Parameshwar, Steven Tsui16.6. Valvular heart disease, Michael Henein16.7.1. Myocarditis, Jay W. Mason16.7.2. The cardiomyopathies: hypertrophic, dilated, restrictive and right ventricular, William J. McKenna, Perry Elliot, and Oliver Guttman16.7.3. Speciac heart muscle disorders16.8. Pericardial disease, Michael Henein16.9.1. Acute rheumatic fever, Jonathan R. Carapetis16.9.2. Endocarditis, James L. Harrison, Bernard D. Prendergast, and William A. Littler16.9.3. Cardiac disease in HIV infection, Peter F. Currie16.9.4. Cardiovascular syphilis, Krishna Somers16.10. Tumours of the heart, Thomas A. Traill16.11. Cardiac involvement in genetic disease, Thomas A. Traill16.12. Congenital heart disease in the adult, S. A. Thorne16.13.1. Biology & pathology of atherosclerosis, Robin P. Choudhury, Edward A. Fisher16.13.2. Coronary heart disease: epidemiology and prevention, Goodarz Danaei, Kazem Rahimi16.13.3. Management of stable angina, Adam D. Timmis16.13.4. Management of acute coronary syndromes, Keith A. A. Fox, Rajesh K. Kharbanda16.13.5. Percutaneous interventional cardiac procedures, Edward D. Folland16.13.6. Coronary artery bypass and valve surgery, Rana Sayeed, David Taggart16.14.1. Acute aortic syndromes, Andrew R. J. Mitchell, James D. Newton, and Adrian P. Banning16.14.2. Peripheral arterial disease, Janet Powell, Alun Davies16.14.3. Cholesterol embolism, Christopher Dudley16.15.1. Structure and function of the pulmonary circulation, Nicholas W. Morrell16.15.2. Pulmonary hypertension, Nicholas W. Morrell16.16.1. Deep venous thrombosis and pulmonary embolism, Paul D. Stein, Fadi Matta, and John D. Firth16.16.2. Therapeutic anticoagulation, David Keeling16.17.1. Essential hypertension: definition, epidemiology and pathophysiology, Bryan Williams16.17.2. Essential hypertension: diagnosis, assessment and treatment, Bryan Williams, John D. Firth16.17.3. Secondary hypertension, Morris J. Brown, Fraz Mir16.17.4. Mendelian disorders causing hypertension, Nilesh J. Samani, Maciej Tomaszewski16.17.5. Hypertensive urgencies and emergencies, Gregory Y. H. Lip, Gareth Beevers16.18. Chronic peripheral oedema and lymphoedema, Peter S. Mortimer16.19. Idiopathic oedema of women, John D. Firth Section 17 - Critical care17.1. The clinical approach to the patient who is very ill, Carole Foot, Liz Hickson17.2. Cardiac arrest, Gavin Perkins, Jasmeet Soar, Jerry P. Nolan, and David A. Gabbott, 17.3. Anaphylaxis, Anthony F. T. Brown17.4. Preparing patients with medical conditions for major surgery, Rupert Pearse, Tom Abbott17.5. Acute respiratory failure, Mark Griffiths, Simon Finney, Jeremy Cordingley, and Susannah Leaver, 17.6. The circulation and circulatory support in the critically ill, Michael Pinsky17.7. Management of raised intracranial pressure, David K. Menon17.8. Sedation and analgesia in the ICU, Michael Reade17.9. Metabolic and endocrine changes in acute and chronic critical illness, Greet Van den Berghe, Eva Boonen17.10. Palliative and end of life care in the ICU, Philip Levin, Charles Sprung17.11. Neurological death and organ donation, Paul Murphy17.12. Medical problems in ICU survivors, T Jack Iwashyna, Mark Mikkelsen Section 18 - Respiratory medicine18.1.1. The upper respiratory tract, Pallav Shah18.1.2. Airways and alveoli, Pallav Shah18.2. The clinical presentation of respiratory disease, Samuel Kemp, Julian Hopkin18.3.1. Respiratory function tests, G. J. Gibson18.3.2. Thoracic imaging, Sue Copley18.3.3. Bronchoscopy, thoracoscopy and tissue biopsy, Pallav Shah18.4.1. Upper respiratory tract infections, Paul Little18.4.2. Pneumonia in the normal host, Wei Shen Lim18.4.3. Nosocomial pneumonia, Wei Shen Lim18.4.4. Mycobacteria, Onn Min Kon, Hannah Jarvis18.4.5. Pulmonary complications of HIV infection, Anton Pozniak, Julia Choy, 18.5.1. Upper airway obstruction, Matthew Hind, James Hull18.5.2. Sleep-related breathing disorders, Mary Morrell, Matthew Hind, Julia Kelly, and Alison McMillan18.6. Allergic rhinitis, S. R. Durham, Hesham Saleh18.7. Asthma, Andrew Menzies-Gow, Alexandra Nanzer-Kelly18.8. Chronic obstructive pulmonary disease, Nicholas Hopkinson18.9. Bronchiectasis, Wilson Robert18.10. Cystic fibrosis, Andrew Bush, Caroline Elston18.11.1. Diffuse parenchymal lung disease: an introduction, Athol U. Wells, Felicia Teo18.11.2. Idiopathic pulmonary fibrosis, Athol U. Wells, P. Molyneaux, and A. G. Nicholson18.11.3. Bronchiolitis obliterans and cryptogenic organising pneumonia, Athol U. Wells, V. Kouranos18.11.4. The lung in autoimmune rheumatic disorders, Athol U. Wells, M. Kokosi18.11.5. The lung in va

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