{"product_id":"principles-of-virology-multi-volume-asm-books-5th-ed","title":"Principles of Virology, Multi-Volume (ASM Books) (5TH ed.)","description":"\n\u003ctable align=\"center\" border=\"0\" cellpadding=\"2\" cellspacing=\"0\" width=\"100%\"\u003e\n\u003ctr\u003e\n\u003ctd class=\"productDetailSmallElements\"\u003e\n\u003cp\u003e\n\u003cstrong\u003eBrief Description\u003c\/strong\u003e:\u003cbr\u003e\n\t\t\t\t\t\t\t\t\"All five editions of this textbook have been written according to the authors' philosophy that the best approach to teaching introductory virology is by emphasizing shared principles. Studying the common steps of the viral reproductive cycle illustrated with a set of representative viruses, and considering mechanisms by which these viruses can cause disease, provides an integrated overview of the biology of these infectious agents. Such knowledge cannot be acquired by learning a collection of facts about individual viruses. Consequently, the major goal of this book is to define and illustrate the basic principles of virus biology. In this information-rich age, the quantity of data describing any given virus can be overwhelming, if not indigestible, for student and expert alike. The urge to write more and more about less and less is the curse of reductionist science and the bane of those who write textbooks meant to be used by students. In the fifth edition, we continue to distill information with the intent of extracting essential principles, while providing descriptions of how the information was acquired, and tools to encourage our readers' exploration of the primary literature. Boxes are used to emphasize major principles and to provide supplementary material of relevance, from explanations of terminology to descriptions of trailblazing experiments. Our goal is to illuminate process and strategy as opposed to listing facts and figures. In an effort to make the book readable, we have been selective in our choice of viruses that are used as examples. The encyclopedic Fields' Virology (Knipe DM, Howley PM (ed). 2020. Fields Virology, 7th ed. Lippincott Williams \u0026amp; Wilkins, Philadelphia, PA.) is recommended as a resource for detailed reviews of specific virus families\"--\u003cbr\u003e\u003cbr\u003e\n\u003cstrong\u003eJacket Description\/Back\u003c\/strong\u003e:\u003cbr\u003e\n\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003ePrinciples of Virology\u003c\/i\u003e, the leading virology textbook in use, is an extremely valuable and highly informative presentation of virology at the interface of modern cell biology and immunology. This text utilizes a uniquely rational approach by highlighting common principles and processes across all viruses. Using a set of representative viruses to illustrate the breadth of viral complexity, students are able to under-stand viral reproduction and pathogenesis and are equipped with the necessary tools for future encounters with new or understudied viruses.\u003cbr\u003e \u003cbr\u003e This fifth edition was updated to keep pace with the ever-changing field of virology. In addition to the beloved full-color illustrations, video interviews with leading scientists, movies, and links to exciting blogposts on relevant topics, this edition includes study questions and active learning puzzles in each chapter, as well as short descriptions regarding the key messages of references of special interest. \u003cbr\u003e \u003cbr\u003e \u003ci\u003eVolume I: Molecular Biology\u003c\/i\u003e focuses on the molecular processes of viral reproduction, from entry through release. \u003ci\u003eVolume II: Pathogenesis and Control\u003c\/i\u003e addresses the interplay between viruses and their host organisms, on both the micro- and macroscale, including chapters on public health, the immune response, vaccines and other antiviral strategies, viral evolution, and a brand new chapter on the therapeutic uses of viruses. These two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to internet resources.\u003cbr\u003e \u003cbr\u003e \u003ci\u003ePrinciples of Virology, Fifth Edition\u003c\/i\u003e, is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. This edition carefully reflects the results of extensive vetting and feedback received from course instructors and students, making this renowned textbook even more appropriate for undergraduate and graduate courses in virology, microbiology, and infectious diseases.\u003c\/p\u003e\n\u003cbr\u003e\u003cbr\u003e\n\u003cstrong\u003eBiographical Note\u003c\/strong\u003e:\u003cbr\u003e\n\u003cp\u003e\u003cb\u003eJane Flint\u003c\/b\u003e is Professor Emerita of Molecular Biology at Princeton University. Dr. Flint's research focused on investigation of the mechanisms by which viral gene products modulate host pathways and antiviral defenses to allow efficient reproduction in normal human cells of adenoviruses, viruses that are used in such therapeutic applications as gene transfer and cancer treatment. \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eVincent R. Racaniello\u003c\/b\u003e is Higgins Professor of Microbiology \u0026amp; Immunology at Columbia University Vagelos College of Physicians \u0026amp; Surgeons. Dr. Racaniello has been studying viruses for over 40 years, including polio- virus, rhinovirus, enteroviruses, hepatitis C virus, and Zika virus. He blogs about virus-es at virology.ws and is host of This Week in Virology. \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGlenn F. Rall\u003c\/b\u003e is a Professor and the Chief Academic Officer at the Fox Chase Cancer Center, and is an Adjunct Professor in the Microbiology and Immunology departments at the University of Pennsylvania, as well as Thomas Jefferson, Drexel, and Temple Universities. Dr. Rall studies viral infections of the brain and the immune responses to those infections, with the goal of defining how viruses contribute to disease. \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eTheodora Hatziioannou\u003c\/b\u003e is a Research Associate Professor at Rockefeller University and is actively involved in teaching programs at Albert Einstein College of Medicine. Dr. Hatziioannou has worked on multiple viruses with a focus on retroviruses and the molecular mechanisms that govern virus tropism and on the improvement of animal models for human disease. \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eAnna Marie Skalka\u003c\/b\u003e is a Professor Emerita and former Senior Vice President for Basic Research at the Fox Chase Cancer Center. Dr. Skalka is internationally recognized for her contributions to the understanding of the biochemical mechanisms by which retroviruses replicate and insert their genetic material into the host genome, as well as her research into other molecular aspects of retrovirus biology.\u003c\/p\u003e\n\u003cbr\u003e\u003cbr\u003e\n\u003cstrong\u003eTable of Contents\u003c\/strong\u003e:\u003cbr\u003e\n\u003cb\u003eVolume 1\u003c\/b\u003e\n\u003cbr\u003e\n\u003cp\u003ePreface\u003c\/p\u003e\n\u003cp\u003eAcknowledgments\u003c\/p\u003e\n\u003cp\u003eAbout the Authors\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePART I: The Science of Virology\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e1 Foundations\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eLuria's Credo\u003c\/p\u003e\n\u003cp\u003eViruses Defined\u003c\/p\u003e\n\u003cp\u003eWhy We Study Viruses\u003c\/p\u003e\n\u003cp\u003eViruses Are Everywhere\u003c\/p\u003e\n\u003cp\u003eViruses Infect All Living Things\u003c\/p\u003e\n\u003cp\u003eViruses Can Cause Human Disease\u003c\/p\u003e\n\u003cp\u003eViruses Can Be Beneficial\u003c\/p\u003e\n\u003cp\u003eViruses \"R\" Us\u003c\/p\u003e\n\u003cp\u003eViruses Can Cross Species Boundaries\u003c\/p\u003e\n\u003cp\u003eViruses Are Unique Tools To Study Biology\u003c\/p\u003e\n\u003cp\u003eVirus Prehistory\u003c\/p\u003e\n\u003cp\u003eViral Infections in Antiquity\u003c\/p\u003e\n\u003cp\u003eThe First Vaccines Microorganisms as Pathogenic Agents\u003c\/p\u003e\n\u003cp\u003eDiscovery of Viruses\u003c\/p\u003e\n\u003cp\u003eThe Defining Properties of Viruses\u003c\/p\u003e\n\u003cp\u003eThe Structural Simplicity of Virus Particles\u003c\/p\u003e\n\u003cp\u003eThe Intracellular Parasitism of Viruses\u003c\/p\u003e\n\u003cp\u003eCataloging Animal Viruses\u003c\/p\u003e\n\u003cp\u003eThe Classical System\u003c\/p\u003e\n\u003cp\u003eClassification by Genome Type: the Baltimore System\u003c\/p\u003e\n\u003cp\u003eA Common Strategy for Viral Propagation\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2 The Infectious Cycle\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eThe Infectious Cycle\u003c\/p\u003e\n\u003cp\u003eThe Cell\u003c\/p\u003e\n\u003cp\u003eEntering Cells\u003c\/p\u003e\n\u003cp\u003eViral RNA Synthesis\u003c\/p\u003e\n\u003cp\u003eViral Protein Synthesis\u003c\/p\u003e\n\u003cp\u003eViral Genome Replication\u003c\/p\u003e\n\u003cp\u003eAssembly of Progeny Virus Particles\u003c\/p\u003e\n\u003cp\u003eViral Pathogenesis\u003c\/p\u003e\n\u003cp\u003eOvercoming Host Defenses\u003c\/p\u003e\n\u003cp\u003eCultivation of Viruses\u003c\/p\u003e\n\u003cp\u003eCell Culture\u003c\/p\u003e\n\u003cp\u003eEmbryonated Eggs\u003c\/p\u003e\n\u003cp\u003eLaboratory Animals\u003c\/p\u003e\n\u003cp\u003eAssay of Viruses\u003c\/p\u003e\n\u003cp\u003eMeasurement of Infectious Units\u003c\/p\u003e\n\u003cp\u003eEfficiency of Plating\u003c\/p\u003e\n\u003cp\u003eMeasurement of Virus Particles\u003c\/p\u003e\n\u003cp\u003eViral Reproduction: the Burst Concept\u003c\/p\u003e\n\u003cp\u003eThe One-Step Growth Cycle\u003c\/p\u003e\n\u003cp\u003eOne-Step Growth Analysis: a Valuable Tool for Studying Animal Viruses\u003c\/p\u003e\n\u003cp\u003eGlobal Analysis\u003c\/p\u003e\n\u003cp\u003eDNA Microarrays\u003c\/p\u003e\n\u003cp\u003eMass Spectrometry\u003c\/p\u003e\n\u003cp\u003eProtein-Protein Interactions\u003c\/p\u003e\n\u003cp\u003eSingle-Cell Virology\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePART II: Molecular Biology\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e3 Genomes and Genetics\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eGenome Principles and the Baltimore System\u003c\/p\u003e\n\u003cp\u003eStructure and Complexity of Viral Genomes\u003c\/p\u003e\n\u003cp\u003eDNA Genomes\u003c\/p\u003e\n\u003cp\u003eRNA Genomes\u003c\/p\u003e\n\u003cp\u003eWhat Do Viral Genomes Look Like?\u003c\/p\u003e\n\u003cp\u003eCoding Strategies\u003c\/p\u003e\n\u003cp\u003eWhat Can Viral Sequences Tell Us?\u003c\/p\u003e\n\u003cp\u003eThe \"Big and Small\" of Viral Genomes: Does Size Matter?\u003c\/p\u003e\n\u003cp\u003eThe Origin of Viral Genomes\u003c\/p\u003e\n\u003cp\u003eGenetic Analysis of Viruses\u003c\/p\u003e\n\u003cp\u003eClassical Genetic Methods\u003c\/p\u003e\n\u003cp\u003eEngineering Mutations into Viral Genomes\u003c\/p\u003e\n\u003cp\u003eEngineering Viral Genomes: Viral Vectors\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4 Structure\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eFunctions of the Virion\u003c\/p\u003e\n\u003cp\u003eNomenclature\u003c\/p\u003e\n\u003cp\u003eMethods for Studying Virus Structure\u003c\/p\u003e\n\u003cp\u003eBuilding a Protective Coat\u003c\/p\u003e\n\u003cp\u003eHelical Structures\u003c\/p\u003e\n\u003cp\u003eCapsids with Icosahedral Symmetry\u003c\/p\u003e\n\u003cp\u003eOther Capsid Architectures\u003c\/p\u003e\n\u003cp\u003ePackaging the Nucleic Acid Genome\u003c\/p\u003e\n\u003cp\u003eDirect Contact of the Genome with a Protein Shell\u003c\/p\u003e\n\u003cp\u003ePackaging by Specialized Viral Proteins\u003c\/p\u003e\n\u003cp\u003ePackaging by Cellular Proteins\u003c\/p\u003e\n\u003cp\u003eViruses with Envelopes\u003c\/p\u003e\n\u003cp\u003eViral Envelope Components\u003c\/p\u003e\n\u003cp\u003eSimple Enveloped Viruses: Direct Contact of External Proteins with the Capsid or Nucleocapsid\u003c\/p\u003e\n\u003cp\u003eEnveloped Viruses with an Additional Protein Layer\u003c\/p\u003e\n\u003cp\u003eLarge Viruses with Multiple\u003c\/p\u003e\n\u003cp\u003eStructural Elements Particles with Helical or Icosahedral Parts Alternative Architectures\u003c\/p\u003e\n\u003cp\u003eOther Components of Virions\u003c\/p\u003e\n\u003cp\u003eEnzymes\u003c\/p\u003e\n\u003cp\u003eOther Viral Proteins\u003c\/p\u003e\n\u003cp\u003eCellular Macromolecules\u003c\/p\u003e\n\u003cp\u003eMechanical Properties of Virus Particles\u003c\/p\u003e\n\u003cp\u003eInvestigation of Mechanical Properties of Virus Particles\u003c\/p\u003e\n\u003cp\u003eStabilization and Destabilization of Virus Particles\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e5 Attachment and Entry\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eAttachment of Virus Particles to Cells\u003c\/p\u003e\n\u003cp\u003eGeneral Principles\u003c\/p\u003e\n\u003cp\u003eIdentification of Receptors for Virus Particles\u003c\/p\u003e\n\u003cp\u003eVirus-Receptor Interactions\u003c\/p\u003e\n\u003cp\u003eEntry into Cells\u003c\/p\u003e\n\u003cp\u003eVirus-induced Signaling via Cell Receptors\u003c\/p\u003e\n\u003cp\u003eRoutes of entry\u003c\/p\u003e\n\u003cp\u003eMembrane Fusion\u003c\/p\u003e\n\u003cp\u003eIntracellular Trafficking and Uncoating\u003c\/p\u003e\n\u003cp\u003eMovement of Viral and Subviral Particles within Cells\u003c\/p\u003e\n\u003cp\u003eUncoating of enveloped viruses\u003c\/p\u003e\n\u003cp\u003eUncoating of non-enveloped viruses\u003c\/p\u003e\n\u003cp\u003eImport of Viral Genomes into the Nucleus\u003c\/p\u003e\n\u003cp\u003eThe Nuclear Pore Complex\u003c\/p\u003e\n\u003cp\u003eNuclear Localization Signals\u003c\/p\u003e\n\u003cp\u003eImport of RNA Genomes\u003c\/p\u003e\n\u003cp\u003eImport of DNA Genomes\u003c\/p\u003e\n\u003cp\u003eImport of Retroviral Genomes\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e6 Synthesis of RNA from RNA Templates\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eThe Nature of the RNA Template\u003c\/p\u003e\n\u003cp\u003eSecondary Structures in Viral RNA\u003c\/p\u003e\n\u003cp\u003eNaked or Nucleocapsid RNA\u003c\/p\u003e\n\u003cp\u003eThe RNA Synthesis Machinery\u003c\/p\u003e\n\u003cp\u003eIdentification of RNA-Dependent RNA Polymerases\u003c\/p\u003e\n\u003cp\u003eThree-Dimensional Structures of RNA-Dependent RNA Polymerases\u003c\/p\u003e\n\u003cp\u003eMechanisms of RNA Synthesis\u003c\/p\u003e\n\u003cp\u003eInitiation\u003c\/p\u003e\n\u003cp\u003eCapping\u003c\/p\u003e\n\u003cp\u003eElongation\u003c\/p\u003e\n\u003cp\u003eFunctions of Additional Polymerase Domains\u003c\/p\u003e\n\u003cp\u003eRNA polymerase Oligomerization\u003c\/p\u003e\n\u003cp\u003eTemplate Specificity\u003c\/p\u003e\n\u003cp\u003eUnwinding the RNA Template\u003c\/p\u003e\n\u003cp\u003eRole of Cellular Proteins\u003c\/p\u003e\n\u003cp\u003eParadigms for Viral RNA Synthesis\u003c\/p\u003e\n\u003cp\u003e(+) Strand RNA\u003c\/p\u003e\n\u003cp\u003eSynthesis of Nested Subgenomic mRNAs\u003c\/p\u003e\n\u003cp\u003e(-) Strand RNA\u003c\/p\u003e\n\u003cp\u003eAmbisense RNA\u003c\/p\u003e\n\u003cp\u003eDouble-Stranded RNA\u003c\/p\u003e\n\u003cp\u003eUnique Mechanisms of mRNA and Genome Synthesis of Hepatitis Delta Satellite Virus\u003c\/p\u003e\n\u003cp\u003eDo Ribosomes and RNA Polymerases Collide?\u003c\/p\u003e\n\u003cp\u003eOrigins of Diversity in RNA Virus Genomes\u003c\/p\u003e\n\u003cp\u003eMisincorporation of Nucleotides\u003c\/p\u003e\n\u003cp\u003eSegment Reassortment and RNA Recombination\u003c\/p\u003e\n\u003cp\u003eRNA Editing\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e7 Synthesis of RNA from DNA Templates\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eProperties of Cellular RNA Polymerases That Transcribe Viral DNA\u003c\/p\u003e\n\u003cp\u003eSome Viral Genomes Must Be Converted to Templates Suitable for Transcription\u003c\/p\u003e\n\u003cp\u003eTranscription by RNA Polymerase II\u003c\/p\u003e\n\u003cp\u003eRegulation of RNA Polymerase II Transcription\u003c\/p\u003e\n\u003cp\u003eCommon Properties of Proteins That Regulate Transcription\u003c\/p\u003e\n\u003cp\u003eTranscription of Viral DNA Templates by the Cellular Machinery Alone\u003c\/p\u003e\n\u003cp\u003eViral Proteins That Govern Transcription of DNA Templates\u003c\/p\u003e\n\u003cp\u003ePatterns of Regulation\u003c\/p\u003e\n\u003cp\u003eThe Human Immunodeficiency Virus Type 1 Tat Protein Autoregulates Transcription\u003c\/p\u003e\n\u003cp\u003eThe Transcriptional Cascades of DNA Viruses\u003c\/p\u003e\n\u003cp\u003eEntry into One of Two Alternative Transcriptional Programs\u003c\/p\u003e\n\u003cp\u003eTranscription of Viral Genes by RNA Polymerase III\u003c\/p\u003e\n\u003cp\u003eThe VA-RNA I Promoter\u003c\/p\u003e\n\u003cp\u003eInhibition of the Cellular Transcriptional Machinery\u003c\/p\u003e\n\u003cp\u003eUnusual Functions of Cellular Transcription Components in Virus-Infected Cells\u003c\/p\u003e\n\u003cp\u003eViral DNA-Dependent RNA Polymerases\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e8 Processing\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eCovalent Modification during Viral Pre-mRNA Processing\u003c\/p\u003e\n\u003cp\u003eCapping the 5′ Ends of Viral mRNA\u003c\/p\u003e\n\u003cp\u003eSynthesis of 3′ Poly(A) Segments of Viral mRNA\u003c\/p\u003e\n\u003cp\u003eInternal Methylation of Adenosine Residues\u003c\/p\u003e\n\u003cp\u003eSplicing of Viral Pre-mRNA\u003c\/p\u003e\n\u003cp\u003eRegulated Processing of Viral Pre-mRNA\u003c\/p\u003e\n\u003cp\u003eEditing of Viral mRNAs\u003c\/p\u003e\n\u003cp\u003eExport of RNAs from the Nucleus\u003c\/p\u003e\n\u003cp\u003eThe Cellular Export Machinery Export of Viral mRNA\u003c\/p\u003e\n\u003cp\u003ePosttranscriptional Regulation of Viral or Cellular Gene Expression by Viral Proteins\u003c\/p\u003e\n\u003cp\u003eTemporal Control of Viral Gene Expression\u003c\/p\u003e\n\u003cp\u003eViral Proteins Can Inhibit Cellular mRNA Production\u003c\/p\u003e\n\u003cp\u003eRegulation of Turnover of Viral and Cellular mRNAs in the Cytoplasm\u003c\/p\u003e\n\u003cp\u003eIntrinsic Turnover\u003c\/p\u003e\n\u003cp\u003eRegulation of mRNA Stability by Viral Proteins\u003c\/p\u003e\n\u003cp\u003emRNA Stabilization Can Facilitate Transformation\u003c\/p\u003e\n\u003cp\u003eNonsense-Mediated mRNA Decay\u003c\/p\u003e\n\u003cp\u003eNoncoding RNAs\u003c\/p\u003e\n\u003cp\u003eSmall Interfering RNAs and Micro-RNAs\u003c\/p\u003e\n\u003cp\u003eLong Noncoding RNAs\u003c\/p\u003e\n\u003cp\u003eCircular RNAs\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e9 Replication of DNA Genomes\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eDNA Synthesis by the Cellular Replication Machinery\u003c\/p\u003e\n\u003cp\u003eEukaryotic Replicons\u003c\/p\u003e\n\u003cp\u003eCellular Replication Proteins\u003c\/p\u003e\n\u003cp\u003eMechanisms of Viral DNA Synthesis\u003c\/p\u003e\n\u003cp\u003eLessons from Simian Virus 40\u003c\/p\u003e\n\u003cp\u003eReplication of Other Viral DNA Genomes\u003c\/p\u003e\n\u003cp\u003eProperties of Viral Replication Origins\u003c\/p\u003e\n\u003cp\u003eRecognition of Viral Replication Origins\u003c\/p\u003e\n\u003cp\u003eViral DNA Synthesis Machines\u003c\/p\u003e\n\u003cp\u003eResolution and Processing of Viral Replication Products\u003c\/p\u003e\n\u003cp\u003eExponential Accumulation of Viral Genomes\u003c\/p\u003e\n\u003cp\u003eViral Proteins Can Induce Synthesis of Cellular Replication Proteins\u003c\/p\u003e\n\u003cp\u003eSynthesis of Viral Replication Machines and Accessory Enzymes\u003c\/p\u003e\n\u003cp\u003eViral DNA Replication Independent of Cellular Proteins\u003c\/p\u003e\n\u003cp\u003eDelayed Synthesis of Structural Proteins Prevents Premature Packaging of DNA Templates\u003c\/p\u003e\n\u003cp\u003eInhibition of Cellular DNA Synthesis\u003c\/p\u003e\n\u003cp\u003eSynthesis of Viral DNA in Specialized Intracellular Compartments\u003c\/p\u003e\n\u003cp\u003eLimited Replication of Viral DNA Genomes\u003c\/p\u003e\n\u003cp\u003eIntegrated Parvoviral DNA Can Be Replicated as Part of the Cellular Genome\u003c\/p\u003e\n\u003cp\u003eDifferent Viral Origins Regulate Replication of Epstein-Barr Virus\u003c\/p\u003e\n\u003cp\u003eLimited and Amplifying Replication from a Single Origin: the Papillomaviruses\u003c\/p\u003e\n\u003cp\u003eOrigins of Genetic Diversity in DNA Viruses\u003c\/p\u003e\n\u003cp\u003eFidelity of Replication by Viral DNA Polymerases\u003c\/p\u003e\n\u003cp\u003eModulation of the DNA Damage Response\u003c\/p\u003e\n\u003cp\u003eRecombination of Viral Genomes\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e10 Reverse Transcription and Integration\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eRetroviral Reverse Transcription\u003c\/p\u003e\n\u003cp\u003eDiscovery\u003c\/p\u003e\n\u003cp\u003eImpact\u003c\/p\u003e\n\u003cp\u003eThe Process of Reverse Transcription\u003c\/p\u003e\n\u003cp\u003eGeneral Properties and Structure of Retroviral Reverse Transcriptases\u003c\/p\u003e\n\u003cp\u003eOther Examples of Reverse Transcription\u003c\/p\u003e\n\u003cp\u003eRetroviral DNA Integration\u003c\/p\u003e\n\u003cp\u003eThe Pathway of Integration: Integrase-Catalyzed Steps\u003c\/p\u003e\n\u003cp\u003eIntegrase Structure and Mechanism\u003c\/p\u003e\n\u003cp\u003eHepadnaviral Reverse Transcription\u003c\/p\u003e\n\u003cp\u003eA DNA Virus with Reverse Transcriptase\u003c\/p\u003e\n\u003cp\u003eThe Process of Hepadnaviral Reverse Transcription\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e11 Protein Synthesis\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eMechanisms of Eukaryotic Protein Synthesis\u003c\/p\u003e\n\u003cp\u003eGeneral Structure of Eukaryotic mRNA\u003c\/p\u003e\n\u003cp\u003eThe Translation Machinery\u003c\/p\u003e\n\u003cp\u003eInitiation\u003c\/p\u003e\n\u003cp\u003eElongation and Termination\u003c\/p\u003e\n\u003cp\u003eThe Diversity of Viral Translation Strategies\u003c\/p\u003e\n\u003cp\u003ePolyprotein Synthesis\u003c\/p\u003e\n\u003cp\u003eLeaky Scanning\u003c\/p\u003e\n\u003cp\u003eReinitiation\u003c\/p\u003e\n\u003cp\u003eStopGo Translation\u003c\/p\u003e\n\u003cp\u003eSuppression of Termination\u003c\/p\u003e\n\u003cp\u003eRibosomal Frameshifting\u003c\/p\u003e\n\u003cp\u003eBicistronic mRNAs\u003c\/p\u003e\n\u003cp\u003eRegulation of Translation during Viral Infection\u003c\/p\u003e\n\u003cp\u003eInhibition of Translation Initiation after Viral Infection\u003c\/p\u003e\n\u003cp\u003eRegulation of eIF4F\u003c\/p\u003e\n\u003cp\u003eRegulation of Poly(A)-Binding Protein Activity\u003c\/p\u003e\n\u003cp\u003eRegulation of eIF3\u003c\/p\u003e\n\u003cp\u003eInterfering with RNA\u003c\/p\u003e\n\u003cp\u003eStress-Associated RNA Granules\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e12 Intracellular Trafficking\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eAssembly within the Nucleus\u003c\/p\u003e\n\u003cp\u003eImport of Viral Proteins for Assembly\u003c\/p\u003e\n\u003cp\u003eAssembly at the Plasma Membrane\u003c\/p\u003e\n\u003cp\u003eTransport of Viral Membrane Proteins to the Plasma Membrane\u003c\/p\u003e\n\u003cp\u003eSorting of Viral Proteins in Polarized Cells\u003c\/p\u003e\n\u003cp\u003eDisruption of the Secretory Pathway in Virus-Infected Cells\u003c\/p\u003e\n\u003cp\u003eSignal Sequence-Independent Transport of Viral Proteins to the Plasma Membrane\u003c\/p\u003e\n\u003cp\u003eInteractions with Internal Cellular Membranes\u003c\/p\u003e\n\u003cp\u003eLocalization of Viral Proteins to Compartments of the Secretory Pathway\u003c\/p\u003e\n\u003cp\u003eLocalization of Viral Proteins to the Nuclear Membrane\u003c\/p\u003e\n\u003cp\u003eTransport of Viral Genomes to Assembly Sites\u003c\/p\u003e\n\u003cp\u003eTransport of Genomic and Pregenomic RNA from the Nucleus to the Cytoplasm\u003c\/p\u003e\n\u003cp\u003eTransport of Genomes from the Cytoplasm to the Plasma Membrane\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e13 Assembly, Release, and Maturation\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eMethods of Studying Virus Assembly and Egress\u003c\/p\u003e\n\u003cp\u003eStructural Studies of Virus Particles\u003c\/p\u003e\n\u003cp\u003eVisualization of Assembly and Exit by Microscopy\u003c\/p\u003e\n\u003cp\u003eBiochemical and Genetic Analyses of Assembly Intermediates\u003c\/p\u003e\n\u003cp\u003eMethods Based on Recombinant DNA Technology\u003c\/p\u003e\n\u003cp\u003eAssembly of Protein Shells\u003c\/p\u003e\n\u003cp\u003eFormation of Structural Units\u003c\/p\u003e\n\u003cp\u003eCapsid and Nucleocapsid Assembly\u003c\/p\u003e\n\u003cp\u003eSelf-Assembly and Assisted Assembly Reactions\u003c\/p\u003e\n\u003cp\u003eSelective Packaging of the Viral Genome and Other Components of Virus Particles\u003c\/p\u003e\n\u003cp\u003eConcerted or Sequential Assembly\u003c\/p\u003e\n\u003cp\u003eRecognition and Packaging of the Nucleic Acid Genome\u003c\/p\u003e\n\u003cp\u003eIncorporation of Enzymes and Other Nonstructural Proteins\u003c\/p\u003e\n\u003cp\u003eAcquisition of an Envelope\u003c\/p\u003e\n\u003cp\u003eSequential Assembly of Internal Components and Budding from a Cellular Membrane\u003c\/p\u003e\n\u003cp\u003eCoordination of the Assembly of Internal Structures with Acquisition of the Envelope\u003c\/p\u003e\n\u003cp\u003eRelease of Virus Particles\u003c\/p\u003e\n\u003cp\u003eAssembly and Budding at the Plasma Membrane\u003c\/p\u003e\n\u003cp\u003eAssembly at Internal Membranes: the Problem of Exocytosis\u003c\/p\u003e\n\u003cp\u003eRelease of Nonenveloped Virus Particles\u003c\/p\u003e\n\u003cp\u003eMaturation of Progeny Virus Particles\u003c\/p\u003e\n\u003cp\u003eProteolytic Processing of Structural Proteins\u003c\/p\u003e\n\u003cp\u003eOther Maturation Reactions\u003c\/p\u003e\n\u003cp\u003eCell-to-Cell Spread\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e14 The Infected Cell\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eSignal Transduction\u003c\/p\u003e\n\u003cp\u003eSignaling Pathways\u003c\/p\u003e\n\u003cp\u003eSignaling in Virus-Infected Cells\u003c\/p\u003e\n\u003cp\u003eGene Expression\u003c\/p\u003e\n\u003cp\u003eInhibition of Cellular Gene Expression\u003c\/p\u003e\n\u003cp\u003eDifferential Regulation of Cellular Gene Expression\u003c\/p\u003e\n\u003cp\u003eMetabolism\u003c\/p\u003e\n\u003cp\u003eMethods To Study Metabolism\u003c\/p\u003e\n\u003cp\u003eGlucose Metabolism\u003c\/p\u003e\n\u003cp\u003eThe Citric Acid Cycle\u003c\/p\u003e\n\u003cp\u003eElectron Transport and Oxidative Phosphorylation\u003c\/p\u003e\n\u003cp\u003eLipid Metabolism\u003c\/p\u003e\n\u003cp\u003eRemodeling of Cellular Organelles\u003c\/p\u003e\n\u003cp\u003eThe Nucleus\u003c\/p\u003e\n\u003cp\u003eThe Cytoplasm\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003eAPPENDIX Structure, Genome Organization, and Infectious Cycles of Viruses Featured in this Book\u003c\/p\u003e\n\u003cp\u003eGlossary\u003c\/p\u003e Index \n\u003cbr\u003e\n\u003cbr\u003e\n\u003cb\u003eVolume 2\u003c\/b\u003e\n\u003cbr\u003e\n\u003cp\u003ePreface\u003c\/p\u003e\n\u003cp\u003eAcknowledgments\u003c\/p\u003e\n\u003cp\u003eAbout the Authors\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e1 Infections of Populations: History and Epidemiology\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction to Viral Pathogenesis\u003c\/p\u003e\n\u003cp\u003eA Brief History of Viral Pathogenesis\u003c\/p\u003e\n\u003cp\u003eThe Relationships among Microbes and the Diseases They Cause\u003c\/p\u003e\n\u003cp\u003eThe First Human Viruses Identified and the Role of Serendipity\u003c\/p\u003e\n\u003cp\u003eNew Methods Facilitate the Study of Viruses as Causes of Disease\u003c\/p\u003e\n\u003cp\u003eViral Epidemics in History\u003c\/p\u003e\n\u003cp\u003eEpidemics Shaped History: the 1793 Yellow Fever Epidemic in Philadelphia\u003c\/p\u003e\n\u003cp\u003eTracking Epidemics by Sequencing: West Nile Virus Spread to the Western Hemisphere\u003c\/p\u003e\n\u003cp\u003eZoonotic Infections and Epidemics Caused by \"New\" Viruses\u003c\/p\u003e\n\u003cp\u003eThe Economic Toll of Viral Epidemics in Livestock\u003c\/p\u003e\n\u003cp\u003ePopulation Density and World Travel Are Accelerators of Viral Transmission\u003c\/p\u003e\n\u003cp\u003eFocus on Frontline Health Care: Ebolavirus in Africa\u003c\/p\u003e\n\u003cp\u003eEmergence of a Birth Defect Associated with Infection: Zika Virus in Brazil\u003c\/p\u003e\n\u003cp\u003eEpidemiology\u003c\/p\u003e\n\u003cp\u003eFundamental Concepts\u003c\/p\u003e\n\u003cp\u003eMethods Used by Epidemiologists\u003c\/p\u003e\n\u003cp\u003eSurveillance\u003c\/p\u003e\n\u003cp\u003eNetwork Theory and Practical Applications\u003c\/p\u003e\n\u003cp\u003eParameters That Govern the Ability of a Virus to Infect a Population\u003c\/p\u003e\n\u003cp\u003eGeography and Population Density\u003c\/p\u003e\n\u003cp\u003eClimate\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2 Barriers to Infection\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eAn Overview of Infection and Immunity\u003c\/p\u003e\n\u003cp\u003eA Game of Chess Played by Masters\u003c\/p\u003e\n\u003cp\u003eInitiating an Infection\u003c\/p\u003e\n\u003cp\u003eSuccessful Infections Must Modulate or Bypass Host Defenses\u003c\/p\u003e\n\u003cp\u003eSkin\u003c\/p\u003e\n\u003cp\u003eRespiratory Tract\u003c\/p\u003e\n\u003cp\u003eAlimentary Tract\u003c\/p\u003e\n\u003cp\u003eEyes\u003c\/p\u003e\n\u003cp\u003eUrogenital Tract\u003c\/p\u003e\n\u003cp\u003ePlacenta\u003c\/p\u003e\n\u003cp\u003eViral Tropism\u003c\/p\u003e\n\u003cp\u003eAccessibility of Viral Receptors\u003c\/p\u003e\n\u003cp\u003eOther Host-Virus Interactions That Regulate the Infectious Cycle\u003c\/p\u003e\n\u003cp\u003eSpread throughout the Host\u003c\/p\u003e\n\u003cp\u003eHematogenous Spread\u003c\/p\u003e\n\u003cp\u003eNeural Spread\u003c\/p\u003e\n\u003cp\u003eOrgan Invasion\u003c\/p\u003e\n\u003cp\u003eEntry into Organs with Sinusoids\u003c\/p\u003e\n\u003cp\u003eEntry into Organs That Lack Sinusoids\u003c\/p\u003e\n\u003cp\u003eOrgans with Dense Basement Membranes\u003c\/p\u003e\n\u003cp\u003eSkin\u003c\/p\u003e\n\u003cp\u003eShedding of Virus Particles\u003c\/p\u003e\n\u003cp\u003eRespiratory Secretions\u003c\/p\u003e\n\u003cp\u003eSaliva\u003c\/p\u003e\n\u003cp\u003eFeces\u003c\/p\u003e\n\u003cp\u003eBlood\u003c\/p\u003e\n\u003cp\u003eUrine\u003c\/p\u003e\n\u003cp\u003eSemen\u003c\/p\u003e\n\u003cp\u003eMilk\u003c\/p\u003e\n\u003cp\u003eSkin Lesions\u003c\/p\u003e\n\u003cp\u003eTears\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e3 The Early Host Response: Cell Autonomous and Innate Immunity\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eThe First Critical Moments: How Do Individual Cells Detect a Virus Infection?\u003c\/p\u003e\n\u003cp\u003eCell Signaling Induced by Viral Entry Receptor Engagement\u003c\/p\u003e\n\u003cp\u003eReceptor-Mediated Recognition of Microbe-Associated Molecular Patterns\u003c\/p\u003e\n\u003cp\u003eCell Intrinsic Defenses\u003c\/p\u003e\n\u003cp\u003eApoptosis (Programmed Cell Death)\u003c\/p\u003e\n\u003cp\u003eNecroptosis and Other Cell Death Pathways\u003c\/p\u003e\n\u003cp\u003eAutophagy\u003c\/p\u003e\n\u003cp\u003eEpigenetic Silencing\u003c\/p\u003e\n\u003cp\u003eCellular Restriction Factors\u003c\/p\u003e\n\u003cp\u003eRNA Interference\u003c\/p\u003e\n\u003cp\u003eCRISPR\u003c\/p\u003e\n\u003cp\u003eThe Continuum Between Intrinsic and Innate Immunity\u003c\/p\u003e\n\u003cp\u003eSecreted Immune Mediators of the Innate Immune Response\u003c\/p\u003e\n\u003cp\u003eOverview of Cytokine Functions\u003c\/p\u003e\n\u003cp\u003eInterferons, Cytokines of Early Warning and Action\u003c\/p\u003e\n\u003cp\u003eChemokines\u003c\/p\u003e\n\u003cp\u003eThe Innate Immune Response\u003c\/p\u003e\n\u003cp\u003eMonocytes\/macrophages\u003c\/p\u003e\n\u003cp\u003eComplement\u003c\/p\u003e\n\u003cp\u003eNatural Killer Cells\u003c\/p\u003e\n\u003cp\u003eInnate Lymphoid Cells\u003c\/p\u003e\n\u003cp\u003eOther Innate Immune Cells of Relevance to Viral Infections\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4 Adaptive Immunity and the Establishment of Memory\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eAttributes of the Host Response\u003c\/p\u003e\n\u003cp\u003eSpeed\u003c\/p\u003e\n\u003cp\u003eDiversity and Specificity\u003c\/p\u003e\n\u003cp\u003eMemory\u003c\/p\u003e\n\u003cp\u003eSelf-Control\u003c\/p\u003e\n\u003cp\u003eLymphocyte Development, Diversity, and Activation\u003c\/p\u003e\n\u003cp\u003eThe Hematopoietic Stem Cell Lineage\u003c\/p\u003e\n\u003cp\u003eThe Two Arms of Adaptive Immunity\u003c\/p\u003e\n\u003cp\u003eThe Major Effectors of the Adaptive Response: B and T Cells\u003c\/p\u003e\n\u003cp\u003eDiverse Receptors Impart Antigen Specificity to B and T Cells\u003c\/p\u003e\n\u003cp\u003eEvents at the Site of Infection Set the Stage for the Adaptive Response\u003c\/p\u003e\n\u003cp\u003eAcquisition of Viral Proteins by Professional Antigen-Presenting Cells Enables Production of Proinflammatory Cytokines and Establishment of Inflammation\u003c\/p\u003e\n\u003cp\u003eActivated Antigen-Presenting Cells Leave the Site of Infection and Migrate to Lymph Nodes\u003c\/p\u003e\n\u003cp\u003eAntigen Processing and Presentation\u003c\/p\u003e\n\u003cp\u003eProfessional Antigen-Presenting Cells Induce Activation via Costimulation\u003c\/p\u003e\n\u003cp\u003ePresentation of Antigens by Class I and Class II MHC Proteins\u003c\/p\u003e\n\u003cp\u003eLymphocyte Activation Triggers Massive Cell Proliferation\u003c\/p\u003e\n\u003cp\u003eThe CTL (Cell-Mediated) Response\u003c\/p\u003e\n\u003cp\u003eCTLs Lyse Virus-Infected Cells\u003c\/p\u003e\n\u003cp\u003eControl of CTL Proliferation\u003c\/p\u003e\n\u003cp\u003eControl of Infection by T Cells without Killing\u003c\/p\u003e\n\u003cp\u003eRashes and Poxes\u003c\/p\u003e\n\u003cp\u003eThe Humoral (Antibody) Response\u003c\/p\u003e\n\u003cp\u003eAntibodies Are Made by Plasma Cells\u003c\/p\u003e\n\u003cp\u003eTypes and Functions of Antibodies\u003c\/p\u003e\n\u003cp\u003eVirus Neutralization by Antibodies\u003c\/p\u003e\n\u003cp\u003eAntibody-Dependent Cell-Mediated Cytotoxicity: Specific Killing by Nonspecific Cells\u003c\/p\u003e\n\u003cp\u003eImmunological Memory\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e5 Patterns and Pathogenesis\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eAnimal Models of Human Diseases\u003c\/p\u003e\n\u003cp\u003ePatterns of Infection\u003c\/p\u003e\n\u003cp\u003eIncubation Periods\u003c\/p\u003e\n\u003cp\u003eMathematics of Growth Correlate with Patterns of Infection\u003c\/p\u003e\n\u003cp\u003eAcute Infections\u003c\/p\u003e\n\u003cp\u003ePersistent Infections\u003c\/p\u003e\n\u003cp\u003eLatent Infections\u003c\/p\u003e\n\u003cp\u003eAbortive Infections\u003c\/p\u003e\n\u003cp\u003eTransforming Infections\u003c\/p\u003e\n\u003cp\u003eViral Virulence\u003c\/p\u003e\n\u003cp\u003eMeasuring Viral Virulence\u003c\/p\u003e\n\u003cp\u003eAlteration of Viral Virulence\u003c\/p\u003e\n\u003cp\u003eViral Virulence Genes\u003c\/p\u003e\n\u003cp\u003ePathogenesis\u003c\/p\u003e\n\u003cp\u003eInfected Cell Lysis\u003c\/p\u003e\n\u003cp\u003eImmunopathology\u003c\/p\u003e\n\u003cp\u003eImmunosuppression Induced by Viral Infection\u003c\/p\u003e\n\u003cp\u003eOncogenesis\u003c\/p\u003e\n\u003cp\u003eMolecular Mimicry\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e6 Cellular Transformation and Oncogenesis\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eProperties of Transformed Cells\u003c\/p\u003e\n\u003cp\u003eControl of Cell Proliferation\u003c\/p\u003e\n\u003cp\u003eOncogenic Viruses\u003c\/p\u003e\n\u003cp\u003eDiscovery of Oncogenic Viruses\u003c\/p\u003e\n\u003cp\u003eViral Genetic Information in Transformed Cells\u003c\/p\u003e\n\u003cp\u003eThe Origin and Nature of Viral Transforming Genes\u003c\/p\u003e\n\u003cp\u003eFunctions of Viral Transforming Proteins\u003c\/p\u003e\n\u003cp\u003eActivation of Cellular Signal Transduction Pathways by Viral Transforming Proteins\u003c\/p\u003e\n\u003cp\u003eViral Signaling Molecules Acquired from the Cell\u003c\/p\u003e\n\u003cp\u003eAlteration of the Production or Activity of Cellular Signal Transduction Proteins\u003c\/p\u003e\n\u003cp\u003eDisruption of Cell Cycle Control Pathways by Viral Transforming Proteins\u003c\/p\u003e\n\u003cp\u003eAbrogation of Restriction Point Control Exerted by the RB Protein\u003c\/p\u003e\n\u003cp\u003eProduction of Virus-Specific Cyclins\u003c\/p\u003e\n\u003cp\u003eInactivation of Cyclin-Dependent Kinase Inhibitors\u003c\/p\u003e\n\u003cp\u003eTransformed Cells Increase in Size and Survive\u003c\/p\u003e\n\u003cp\u003eMechanisms That Permit Survival of Transformed Cells\u003c\/p\u003e\n\u003cp\u003eTumorigenesis Requires Additional Changes in the Properties of Transformed Cells\u003c\/p\u003e\n\u003cp\u003eInhibition of Immune Defenses\u003c\/p\u003e\n\u003cp\u003eOther Mechanisms of Transformation and Oncogenesis by Human Tumor Viruses\u003c\/p\u003e\n\u003cp\u003eNontransducing Oncogenic Retroviruses: Tumorigenesis with Very Long Latency\u003c\/p\u003e\n\u003cp\u003eOncogenesis by Hepatitis Viruses\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e7 Vaccines\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eThe Origins of Vaccination\u003c\/p\u003e\n\u003cp\u003eSmallpox: a Historical Perspective\u003c\/p\u003e\n\u003cp\u003eWorldwide Vaccination Programs Can Be Dramatically Effective\u003c\/p\u003e\n\u003cp\u003eVaccine Basics\u003c\/p\u003e\n\u003cp\u003eImmunization Can Be Active or Passive\u003c\/p\u003e\n\u003cp\u003eActive Vaccination Strategies Stimulate Immune Memory\u003c\/p\u003e\n\u003cp\u003eThe Fundamental Challenge\u003c\/p\u003e\n\u003cp\u003eThe Science and Art of Making Vaccines\u003c\/p\u003e\n\u003cp\u003eInactivated Virus Vaccines\u003c\/p\u003e\n\u003cp\u003eAttenuated Virus Vaccines\u003c\/p\u003e\n\u003cp\u003eSubunit Vaccines\u003c\/p\u003e\n\u003cp\u003eVirus-Like Particles\u003c\/p\u003e\n\u003cp\u003eNucleic Acid Vaccines\u003c\/p\u003e\n\u003cp\u003eVaccine Technology: Delivery and Improving Antigenicity\u003c\/p\u003e\n\u003cp\u003eAdjuvants Stimulate an Immune Response\u003c\/p\u003e\n\u003cp\u003eDelivery and Formulation\u003c\/p\u003e\n\u003cp\u003eImmunotherapy\u003c\/p\u003e\n\u003cp\u003eThe Ongoing Quest for an AIDS Vaccine\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Question Puzzle\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e8 Antiviral Drugs\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e Introduction\u003c\/p\u003e\n\u003cp\u003eA Brief History of Antiviral Drug Discovery\u003c\/p\u003e\n\u003cp\u003eDiscovering Antiviral Compounds\u003c\/p\u003e\n\u003cp\u003eThe Lexicon of Antiviral Discovery\u003c\/p\u003e\n\u003cp\u003eScreening for Antiviral Compounds\u003c\/p\u003e\n\u003cp\u003eComputational Approaches to Drug Discovery\u003c\/p\u003e\n\u003cp\u003eThe Difference between \"R\" and \"D\"\u003c\/p\u003e\n\u003cp\u003eDrug Resistance\u003c\/p\u003e\n\u003cp\u003eExamples of Antiviral Drugs\u003c\/p\u003e\n\u003cp\u003eInhibitors of Virus Attachment and Entry\u003c\/p\u003e\n\u003cp\u003eInhibitors of Viral Nucleic Acid Synthesis\u003c\/p\u003e\n\u003cp\u003eInhibition of Viral Polyprotein Processing and Assembly\u003c\/p\u003e\n\u003cp\u003eInhibition of Virus Particle Release\u003c\/p\u003e\n\u003cp\u003eExpanding Targets for Antiviral Drug Development\u003c\/p\u003e\n\u003cp\u003eAttachment and Entry Inhibitors\u003c\/p\u003e\n\u003cp\u003eNucleic Acid-Based Approaches\u003c\/p\u003e\n\u003cp\u003eProteases and Nucleic Acid Synthesis and Processing Enzymes\u003c\/p\u003e\n\u003cp\u003eVirus Particle Assembly\u003c\/p\u003e\n\u003cp\u003eMicrobicides\u003c\/p\u003e\n\u003cp\u003eTwo Stories of Antiviral Success\u003c\/p\u003e\n\u003cp\u003eCombination Therapy\u003c\/p\u003e\n\u003cp\u003eChallenges Remaining\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e9 Therapeutic Viruses\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e Introduction\u003c\/p\u003e\n\u003cp\u003ePhage Therapy\u003c\/p\u003e\n\u003cp\u003e History\u003c\/p\u003e\n\u003cp\u003e Some Advantages and Limitations of Phage Therapy\u003c\/p\u003e\n\u003cp\u003e Applications in the Clinic and for Disease Prevention\u003c\/p\u003e\n\u003cp\u003e Future Prospects\u003c\/p\u003e\n\u003cp\u003eOncolytic Animal Viruses\u003c\/p\u003e\n\u003cp\u003e From Anecdotal Reports to Controlled Clinical Trials\u003c\/p\u003e\n\u003cp\u003e Rational Design of Oncolytic Viruses\u003c\/p\u003e\n\u003cp\u003e Two Clinically Approved Oncolytic Viruses\u003c\/p\u003e\n\u003cp\u003e Future Directions\u003c\/p\u003e\n\u003cp\u003eGene Therapy\u003c\/p\u003e\n\u003cp\u003e Introduction\u003c\/p\u003e\n\u003cp\u003e Retroviral Vectors\u003c\/p\u003e\n\u003cp\u003e Adenovirus-Associated Virus Vectors\u003c\/p\u003e\n\u003cp\u003e Future Prospects\u003c\/p\u003e\n\u003cp\u003eVaccine Vectors\u003c\/p\u003e\n\u003cp\u003e DNA Viruses\u003c\/p\u003e\n\u003cp\u003e RNA Viruses\u003c\/p\u003e\n\u003cp\u003ePerspectives\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eStudy Questions\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e10 Virus Evolution\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eVirus Evolution\u003c\/p\u003e\n\u003cp\u003eHow Do Virus Populations Evolve?\u003c\/p\u003e\n\u003cp\u003eTwo General Virus Survival Strategies Can Be Distinguished\u003c\/p\u003e\n\u003cp\u003eLarge Numbers of Viral Progeny and Mutants Are Produced in Infected Cells\u003c\/p\u003e\n\u003cp\u003eThe Quasispecies Concept\u003c\/p\u003e\n\u003cp\u003eGenetic Shift and Genetic Drift\u003c\/p\u003e\n\u003cp\u003eFundamental Properties of Viruses That Constrain Evolution\u003c\/p\u003e\n\u003cp\u003eTwo General Pathways for Virus Evolution\u003c\/p\u003e\n\u003cp\u003eEvolution of Virulence\u003c\/p\u003e\n\u003cp\u003eThe Origin of Viruses\u003c\/p\u003e\n\u003cp\u003eWhen and How Did They Arise?\u003c\/p\u003e\n\u003cp\u003eEvolution of Contemporary Eukaryotic Viruses\u003c\/p\u003e\n\u003cp\u003eHost-Virus Relationships Drive Evolution\u003c\/p\u003e\n\u003cp\u003eDNA Virus-Host Relationships\u003c\/p\u003e\n\u003cp\u003eRNA Virus-Host Relationships\u003c\/p\u003e\n\u003cp\u003eThe Host-Virus \"Arms Race\"\u003c\/p\u003e\n\u003cp\u003eLessons from Paleovirology\u003c\/p\u003e\n\u003cp\u003eEndogenous Retroviruses\u003c\/p\u003e\n\u003cp\u003eDNA Fossils Derived from Other RNA Viral Genomes\u003c\/p\u003e\n\u003cp\u003eEndogenous Sequences from DNA Viruses\u003c\/p\u003e\n\u003cp\u003eShort- versus Long-Term Rates of Viral Evolution\u0026lt;\u003c\/p\u003e\n\u003cbr\u003e\u003cbr\u003e\n\u003cstrong\u003ePublisher Marketing\u003c\/strong\u003e:\u003cbr\u003e\n\u003ci\u003ePrinciples of Virology\u003c\/i\u003e, the leading virology textbook in use, is an extremely valuable and highly informative presentation of virology at the interface of modern cell biology and immunology. This text utilizes a uniquely rational approach by highlighting common principles and processes across all viruses. Using a set of representative viruses to illustrate the breadth of viral complexity, students are able to understand viral reproduction and pathogenesis and are equipped with the necessary tools for future encounters with new or understudied viruses. \n\u003cbr\u003e\n\u003cbr\u003eThis fifth edition was updated to keep pace with the ever-changing field of virology. In addition to the beloved full-color illustrations, video interviews with leading scientists, movies, and links to exciting blogposts on relevant topics, this edition includes study questions and active learning puzzles in each chapter, as well as short descriptions regarding the key messages of references of special interest. \n\u003cbr\u003e\n\u003cbr\u003e\n\u003ci\u003eVolume I: Molecular Biology\u003c\/i\u003e focuses on the molecular processes of viral reproduction, from entry through release. \n\u003ci\u003eVolume II: Pathogenesis and Control\u003c\/i\u003e addresses the interplay between viruses and their host organisms, on both the micro- and macroscale, including chapters on public health, the immune response, vaccines and other antiviral strategies, viral evolution, and a brand new chapter on the therapeutic uses of viruses. These two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to internet resources. \n\u003cbr\u003e\n\u003cbr\u003e\n\u003ci\u003ePrinciples of Virology, Fifth Edition\u003c\/i\u003e, is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. This edition carefully reflects the results of extensive vetting and feedback received from course instructors and students, making this renowned textbook even more appropriate for undergraduate and graduate courses in virology, microbiology, and infectious diseases.\u003cbr\u003e\u003cbr\u003e\n\n\u003cbr\u003e\n\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n","brand":"ASM Press","offers":[{"title":"Default Title","offer_id":51502788215062,"sku":"9781683670322","price":168.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0857\/9910\/8886\/files\/9781683670322.jpg?v=1783316854","url":"https:\/\/lusper.myshopify.com\/products\/principles-of-virology-multi-volume-asm-books-5th-ed","provider":"Lusperbooks","version":"1.0","type":"link"}