{"product_id":"dna-damage-dna-repair-and-disease-two-volume-set-chemical-biology-1st-ed","title":"DNA Damage, DNA Repair and Disease: Two-Volume Set (Chemical Biology) (1ST ed.)","description":"\n\u003ctable align=\"center\" border=\"0\" cellpadding=\"2\" cellspacing=\"0\" width=\"100%\"\u003e\n\u003ctr\u003e\n\u003ctd class=\"productDetailSmallElements\"\u003e\n\u003cp\u003e\n\u003cstrong\u003eTable of Contents\u003c\/strong\u003e:\u003cbr\u003e\n\u003c\/p\u003e\n\u003cp\u003eBiomonitoring of DNA Damage in Humans;\u003cbr\u003e Tandem and Clustered Lesions from Radicals in Nucleic Acids from a Single Initial Chemical Event;\u003cbr\u003e Oxidative DNA Damage and Repair in G-Quadruplexes;\u003cbr\u003e Oxidatively Induced DNA Damage: Mechanisms and Measurement;\u003cbr\u003e Oxidation of the C5′ Position in DNA and the Role of Purine 5',8-Cyclo-2'-deoxynucleoside Lesions;\u003cbr\u003e Ferroptosis and Oxidative DNA Damage;\u003cbr\u003e DNA-Protein Cross-Links: Formation, Genotoxicity and Repair;\u003cbr\u003e Substrate Specificities of DNA Glycosylases in vitro and in vivo;\u003cbr\u003e The Special Problems for Base Excision Repair in Coping with Oxidatively-induced DNA Damage;\u003cbr\u003e Genomic Uracil in Biology, Immunity and Cancer;\u003cbr\u003e Alternative DNA Repair Pathways to Handle Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs;\u003cbr\u003e Redox Stress Responses and Human Disease: NTHL1 at the Intersection of DNA Damage Repair and Cancer;\u003cbr\u003e Emerging Roles of Non-Canonical RNA Binding Proteins in Repair of Genome Damage Linked to Human Pathologies;\u003cbr\u003e Modulation of DNA Glycosylase Activities via Small Molecules;\u003cbr\u003e DNA Repair in the Development of Human Diseases and Therapy;\u003cbr\u003e Mechanisms and Maps of Nucleotide Excision Repair;\u003cbr\u003e Emerging Concepts on the Early Steps of Base Excision Repair Pathway with a Focus on Gene Expression;\u003cbr\u003e Base Excision Repair in Plants: Variations on a Theme;\u003cbr\u003e OGG1 at the Crossroads of Inflammation and DNA Base Excision Repair;\u003cbr\u003e Fidelity Mechanisms of DNA Polymerase Beta;\u003cbr\u003e DNA Damage Leads to Neurodegeneration via Mitochondrial Dysfunction;\u003cbr\u003e Emerging Roles of Sirtuins in Chromatin Regulation and DNA Repair Via their NAD+-dependent Activities;\u003cbr\u003e Unique Roles of Human Translesion Synthesis DNA Polymerase;\u003cbr\u003e Replicative and Transcriptional Bypass of Alkylated DNA Lesions in Human Cells;\u003cbr\u003e Mutational Spectra Provide Insight into the Mechanisms Bridging DNA Damage to Genetic Disease;\u003cbr\u003e Evolving DNA Repair Targets for Cancer Therapy;\u003cbr\u003e Basic, Translational and Clinical Relevance of the DNA Repair and Redox Signaling Protein APE1 in Human Diseases;\u003cbr\u003e The role of PARP and the therapeutic potential of PARP inhibitors in cancer;\u003cbr\u003e Translating DNA Adduct Knowledge to Human Prevention Trials;\u003cbr\u003e DNA Damage and the Maintenance of Nuclear Genome Integrity in Aging and Associated Phenotypes;\u003cbr\u003e Gamma- and Ion-beam DNA Radiation Damage: Theory and Experiment;\u003c\/p\u003e\n\u003cbr\u003e\u003cbr\u003e\n\u003cstrong\u003ePublisher Marketing\u003c\/strong\u003e:\u003cbr\u003e\n\u003cp\u003eThe DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.\u003c\/p\u003e\n\u003cbr\u003e\u003cbr\u003e\n\n\u003cbr\u003e\n\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n","brand":"Royal Society of Chemistry","offers":[{"title":"Default Title","offer_id":51502638498070,"sku":"9781839162527","price":522.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0857\/9910\/8886\/files\/9781839162527.jpg?v=1783311996","url":"https:\/\/lusper.myshopify.com\/products\/dna-damage-dna-repair-and-disease-two-volume-set-chemical-biology-1st-ed","provider":"Lusperbooks","version":"1.0","type":"link"}